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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TTK
All Species:
36.97
Human Site:
S537
Identified Species:
67.78
UniProt:
P33981
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33981
NP_003309.2
857
97072
S537
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
Chimpanzee
Pan troglodytes
XP_001146752
857
97034
S537
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
Rhesus Macaque
Macaca mulatta
XP_001111082
778
87619
Q497
C
F
Q
Q
Q
Q
Q
Q
I
P
A
T
P
L
Q
Dog
Lupus familis
XP_539016
855
96614
S534
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
Cat
Felis silvestris
Mouse
Mus musculus
P35761
856
96192
S536
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
Rat
Rattus norvegicus
NP_001101642
835
94323
S515
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512474
935
104827
S548
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
Chicken
Gallus gallus
XP_419867
879
99691
S554
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
Frog
Xenopus laevis
NP_001082090
882
99060
S558
Q
I
G
T
G
G
S
S
K
V
F
Q
V
M
D
Zebra Danio
Brachydanio rerio
Q8AYG3
982
109993
S665
M
I
G
R
G
G
S
S
K
V
Y
Q
V
F
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002301009
818
91361
S524
E
V
M
S
S
S
I
S
N
K
D
G
R
V
K
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565160
777
86358
M496
K
E
D
G
F
I
Y
M
V
L
E
Y
G
E
I
Baker's Yeast
Sacchar. cerevisiae
P54199
764
86809
F483
D
D
S
S
I
D
G
F
K
G
E
I
E
L
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
85.7
87.4
N.A.
74.3
76.9
N.A.
64.2
61
52.8
41.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
87.7
92.6
N.A.
84.8
85.6
N.A.
73.6
74.5
68.4
57
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
6.6
100
N.A.
100
100
N.A.
100
100
80
66.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
6.6
100
N.A.
100
100
N.A.
100
100
100
80
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
23.1
N.A.
N.A.
22.9
22.7
N.A.
Protein Similarity:
40.2
N.A.
N.A.
42.3
44.5
N.A.
P-Site Identity:
13.3
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
8
0
0
8
0
0
0
0
8
0
0
0
16
% D
% Glu:
8
8
0
0
0
0
0
0
0
0
16
0
8
8
0
% E
% Phe:
0
8
0
0
8
0
0
8
0
0
62
0
0
8
0
% F
% Gly:
0
0
70
8
70
70
8
0
0
8
0
8
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
70
0
0
8
8
8
0
8
0
0
8
0
0
8
% I
% Lys:
8
0
0
0
0
0
0
0
77
8
0
0
0
0
8
% K
% Leu:
0
0
0
0
0
0
0
0
0
8
0
0
0
70
8
% L
% Met:
8
0
8
0
0
0
0
8
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
54
% N
% Pro:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
0
% P
% Gln:
62
0
8
8
8
8
8
8
0
0
0
70
0
0
8
% Q
% Arg:
0
0
0
8
0
0
0
0
0
0
0
0
8
0
0
% R
% Ser:
0
0
8
70
8
8
70
77
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
8
0
0
0
0
0
0
0
8
0
0
0
% T
% Val:
0
8
0
0
0
0
0
0
8
70
0
0
70
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
8
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _